Cancer-related distress and fear
How psychological distress and fear of recurrence or progression develop during cancer treatment and survivorship, and how patients experience them.
Research dossier
Psycho-Oncology & Cancer Survivorship
Digital health and responsible AI are methods within this research direction. A working prototype is not evidence of clinical effectiveness, and AI does not replace professional judgement.
Profile and direction
From psychological care to oncology research.
My current direction is psycho-oncology and cancer survivorship. Psychological treatment and assessment in a hospital setting, alongside clinical and translational research, shape the questions I want to pursue.
MSc Psychology with Merit from Bangor University and BSc Psychology from Arizona State University, both completed through English-medium study.
More than five years of frontline health-service experience in China, with continuing work in psychological treatment and assessment.
An intermediate national health professional qualification in psychological therapy, distinct from an employer-issued professional appointment record.
Twelve published journal outputs: eleven English-language PubMed records and one Chinese-language clinical mental health article, with author roles stated individually.
Existing publications connect psychological stress, intervention outcomes, glioma recurrence, and treatment response.
Fear of recurrence or progression, cancer-related sleep disturbance, and survivorship care are next-stage research priorities, rather than an established publication track.
Sleep and patient-reported outcomes
Longitudinal relationships between sleep, distress, daily functioning, and quality of life, using measures that are practical for patients and services.
Psychosocial intervention
Which low-burden psychological interventions may help which patients, and how their effects can be evaluated with meaningful outcomes.
Biobehavioral mechanisms and methods
Testable links between psychological stress, biological processes, and clinical outcomes. Digital health and responsible AI support these questions as methods.
Evidence ledger
What the current record supports.
Education
Psychology across two academic systems
English-medium BSc study at Arizona State University and MSc Psychology with Merit at Bangor University, including dissertation work on autobiographical memory.
Practice
Psychological treatment and assessment
More than five years of frontline health-service experience in China. National qualification, employer appointment, and training are recorded separately in the public CV.
Publications
Twelve published journal outputs
Eleven English-language PubMed records and one Chinese-language journal article, including two Letters. Author order and equal contribution are shown for each record.
Research
A bridge into psycho-oncology
Existing stress, psychological intervention, and glioma research supports the move toward cancer-related fear, sleep, and survivorship questions. Those next-stage topics are not presented as completed studies.
Collaboration
Publication-linked research infrastructure
Named publications and documented contributions link to three registered studies, two BioProjects, and Figshare records. These are collaborative contributions; they do not establish a principal-investigator role or personal ownership of the datasets.
Psychological stress and glioma biology
First-listed and equal-contributing author on the fear-stress and ferroptosis study, linking psychological stress with a testable biological mechanism.
Psychological intervention and outcomes
First-listed author on a Chinese-language clinical study of cyclic breathing and mindfulness in anxiety disorders, connecting psychological intervention with emotional and physiological outcomes.
Neuro-oncology collaboration
Co-authored work on emotional distress, treatment response, tumour evolution, and recurrence, including publisher-confirmed equal contributions on three second-listed-author papers.
Publication-linked registered studies
Collaboration documented through named publications and contributions; no principal-investigator, registrant, sponsor, or study-contact role is claimed.
Publication-linked data repositories
Research records linked to co-authored publications. These do not establish personal ownership, an uploader role, or current access to patient-level data.
Selected publications
Public records, presented at the level they prove.
Four selected records connect psychological stress, intervention, and oncology outcomes. All twelve published journal outputs appear in the public CV, with author roles and publication types.
2023
Fear stress promotes glioma progression through inhibition of ferroptosis by enhancing FSP1 stability.
Clinical and Translational Oncology, 25(5), 1378-1388. DOI: 10.1007/s12094-022-03032-1. PubMed PMID: 36484954.
First-listed author; equal contribution with Sen Hu. Journal article.
Fear stress, ferroptosis and glioma progression: a foundation for investigating psychological stress in oncology.
2025
Effects of cyclic breathing and mindfulness meditation on emotional and physiological states in patients with anxiety disorders.
Journal of Medical Forum, 46(10), 1039-1042, 1049. DOI: 10.20159/j.cnki.jmf.2025.10.007.
First-listed author. Journal article.
Clinical psychological intervention and psychophysiological outcomes. Chinese-language journal article; not a PubMed record.
2026
Emotional distress impairs immune checkpoint blockade efficacy in recurrent high-grade glioma: insights from tumor in situ fluid analysis.
Neuro-Oncology Advances. DOI: 10.1093/noajnl/vdag040. PubMed PMID: 41778154.
Fourth-listed author. Journal article.
Emotional distress, immunotherapy response and outcomes in recurrent high-grade glioma.
2026
Dynamic signature for the effectiveness of anti-PD-1 therapy combined with vascular normalization therapy in recurrent glioblastoma: a randomized phase 2 trial.
Cancer, 132(2), e70253. DOI: 10.1002/cncr.70253. PubMed PMID: 41533333.
Fourth-listed author. Journal article.
Randomized phase 2 trial of anti-PD-1 therapy with vascular normalization in recurrent glioblastoma.
Research questions
Questions that keep the direction concrete.
01
Distress, fear, and sleep over time
How do psychological distress, fear of recurrence or progression, and sleep disturbance evolve together during cancer treatment and survivorship?
02
Psychological and biological outcomes
Which relationships between psychological stress, inflammation, immune processes, and clinical outcomes can be tested in longitudinal research?
03
Useful psychosocial interventions
Which low-burden psychological interventions help which patients, and how can patient-reported outcomes guide their evaluation?
Applied AI and digital health
Implementation evidence with explicit limits.
Mind Portrait
A non-diagnostic self-reflection prototype. My work covers the intended experience, psychological safety boundaries, report design, and AI-assisted implementation.
SeYun Outfit
An iOS outfit-planning product in release preparation. It demonstrates product design, localization, privacy and support work, and AI-assisted implementation; it is not a clinical product.
Public writing and infrastructure
This website and the Survivor Starter Manual connect research communication, public writing, and practical digital delivery.
Collaboration fit matrix
What a collaborator can evaluate quickly.
How existing experience connects to the research questions I want to pursue.
Research area
Psycho-oncology
Current evidence
Published work on fear stress and glioma progression, emotional distress and treatment response, and clinical psychological intervention.
Research fit
Cancer-related distress, fear of recurrence or progression, and psychosocial intervention.
Research area
Assessment and outcomes
Current evidence
Psychology education, hospital-based psychological treatment and assessment, and research on emotional and physiological outcomes.
Research fit
Patient-reported outcomes, sleep and distress trajectories, and practical longitudinal measurement.
Research area
Translational collaboration
Current evidence
Co-authored studies of glioma recurrence, tumour evolution, longitudinal monitoring, and treatment response.
Research fit
Testable psychological-biological relationships and cross-disciplinary oncology research.
Research area
Digital implementation
Current evidence
AI-assisted product definition, prototyping, public communication, and privacy/support infrastructure.
Research fit
Carefully evaluated digital research tools with clear limits and human oversight.
Where this profile can be useful
Fit is overlap, not persuasion.
Psycho-oncology and survivorship collaboration
Research on cancer-related distress, fear of recurrence or progression, sleep, psychosocial intervention, and patient-reported outcomes.
Funded PhD or research opportunities
Projects with a strong match to this research direction and a clear connection between the scientific question, available supervision, and methods.
Clinical and translational collaboration
Work that connects psychological questions with longitudinal outcome observation, recurrence, treatment response, and biobehavioral mechanisms.
Responsible digital implementation
Research-support prototypes, measurement workflows, and clear public communication, with appropriate evaluation and human oversight.
I welcome research conversations that connect psychological care with cancer-related distress, sleep, and survivorship outcomes. Academic collaboration, funded research, and PhD study are possible routes when the scientific fit is strong.
If you arrived from an email I sent, reply to that thread. New academic inquiries or forwarded introductions can use research@chaojiebu.com.